6. bis 10. Oktober 2008
Martin Haase (Greifswald): "Phylogenetics. past, present and future"
Phylogentics has attained a central role in evolutionary biology with relevance in both pure and applied research. Based on a historical account of the development of formalized methodologies in systematics, currently established approaches, viz. maximum parsimony, distance methods, maximum likelihood, and Bayesian inference, will be introduced. Strengths and weakness of these tree-building methods will be discussed. Progress in our understanding of sequence evolution as well as the rapid development of laboratory techniques in an increasing rate of data production more an more push the limits of the standard methods in phylogeny reconstruction. Necessary developments and directions will be pointed.
Karl-Ernst Biebler (Greifswald): "Sequence data and models of inheritance"
Associations and correlations of sequence data and phenomena being interested (e.g. illness X) do not explain any causalities. What can one do? Causalities are formulated as models of inheritance. Genetics was founded by this idea of GREGOR MENDEL. We will define ideal populations and MENDELIAN models of inheritance. How many MENDELIAN models exist? The answer will be given for selected situations. Parameter estimations and their properties are derived. The problem of the model choice is treated. Some extensions of MENDELIAN models are outlined.
Dietmar Cieslik (Greifswald): "Sequence spaces"
We introduce so-called sequence spaces. These are metric spaces whose points are arbitrary words generated by letters from some (finite) alphabet, and the metric measuring „sameness“ of the words which is generated by a cost measure on the alphabet. In this sense, our considerations will play an important rule in the construction of phylogenetic trees, which typically represent the evolutionary history of a collection of extant species or the line of descent.
Georg Füllen (Greifswald): "Homology and Phylogeny − Applications and Large-Scale Analyses"
Phylogenetics and the (underlying) concept of homology wil lbe tested for their applicability to large-scale data analysis in biology and biomedicine. We discuss gene/species trees, homology search in genomic data and protein databases, genome annotation using homology search and phylogenetics, and large-scale automation of phylogenetic analyses (by so-called phylogenomic pipelines).
Andreas Dress (Shanghai) : "Phylogenetic networks"
In the lecture, we will discuss how sequence- and distance data can be used to derive phylogenetic information.
Wissenschaftliche Leitung:
Professor Dr. Karl-Ernst Bieber (Greifswald)
Professor Dr. Dietmar Cieslik (Greifswald)
Professor Dr. Andreas Dress (Shanghai)
Professor Dr. Georg Füllen (Greifswald)
Dr. Martin Haase (Greifswald)
Die Herbstakademie zur Phylogenetischen Kombinatorik steht allen Interessierten offen. Es werden Mathematik- und Informatikkenntnisse vorausgesetzt, wie sie üblicherweise im Grundstudium erworben werden. Die Unterrichtssprache ist Englisch. Es wird keine Teilnahmegebühr erhoben.
Information: tagungsbuero(at)wiko-greifswald.de
Programm der Herbstakademie als pdf-Datei zum Download
Online-Anmeldeformular