Professor Dr. rer. nat. Bärbel Friedrich

Wissenschaftliche Direktorin

Professor Dr. rer. nat. Bärbel Friedrich, geboren 1945 in Göttingen, studierte von 1965 bis 1970 Biologie an der Universität Göttingen und wurde dort 1973 im Fach Mikrobiologie promoviert. Sie forschte 1975 bis 1976 als Postdoc am MIT in Cambridge, USA, und war im Anschluss bis 1984 Wissenschaftliche Mitarbeiterin am Institut für Mikrobiologie der Universität Göttingen. 1985 wurde sie als C4-Professorin für Mikrobiologie an die Freie Universität Berlin berufen. 1994 nahm Professor Friedrich einen Ruf an die Humboldt-Universität zu Berlin an, wo sie bis zu ihrer Pensionierung im Jahr 2013 den Lehrstuhl für Mikrobiologie innehatte. Zu ihren Forschungsschwerpunkten zählen die Funktion und Biosynthese von Metallproteinen, Mechanismen der enzymatischen Katalyse am Beispiel von metallhaltigen Redoxproteinen insbesondere Hydrogenasen und deren biotechnologische Anwendung. Die funktionelle Genomanalyse konzentrierte sich auf fakultativ lithoautotrophe Bakterien. Über die wissenschaftlichen Arbeiten liegen derzeit 200 Publikationen vor. 

Seit 2008 ist Bärbel Friedrich Wissenschaftliche Direktorin des Alfried Krupp Wissenschaftskollegs Greifswald. Sie ist Mitglied der Leopoldina, der Nationalen Akademie der Wissenschaften und war von 2005 bis 2015 deren Vizepräsidentin. 2014 wurde sie in den Universitätsrat Wien berufen. Sie ist ferner Mitglied der Berlin-Brandenburgischen Akademie der Wissenschaften, korrespondierendes Mitglied der Akademie der Wissenschaften Göttingen und korrespondierendes Mitglied der Nordrhein-Westfälischen Akademie der Wissenschaften. Von 1997 bis 2003 war sie Vizepräsidentin der Deutschen Forschungsgemeinschaft und gehörte von 2003 bis 2005 der Enquete-Kommission des Bundestages "Ethik und Recht in der modernen Medizin" an. Bärbel Friedrich erhielt zahlreiche Auszeichnungen, darunter den Arthur-Burkhardt-Preis, das Verdienstkreuz am Bande der Bundesrepublik Deutschland und die Verdienstmedaille der Leopoldina.

Veröffentlichungen der Wissenschaftlichen Direktorin
  • Bürstel, I., Siebert, E., Frielingsdorf, S., Zebger, I., Friedrich, B., Lenz, O.2016. CO synthesized from the central one-carbon pool as source for the iron carbonyl in O2-tolerant [NiFe]-hydrogenase. Proc Nath Acad Sci USA 113: 14722-14726. PubMed
  • Friedrich, B. 2015. Policy advice in a world of global callenges: the role of national academies. Proceedings of the 14th Baltic converence on Intellectuel Cooperation, p. 34-39.
  • Kohlmann, Y., Pohlmann,A., Schwartz, E, Zühlke, D., Otto, A., Albrecht, D, Grimmler, C., Ehrenreich, A., Voigt, B. , Becher, D., Hecker, M., Friedrich, B., Cramm, R. 2014. Coping with Anoxia: A Comprehensive Proteomic and Transcriptomic Survey of Denitrification. J. Proteome. Res. 13:4325-4338
  • Frielingsdorf, S., Fritsch, J., Schmidt, A., Hammer, M., Lowenstein, J., Siebert, E., Pelmenschikov, V., Jaenicke, T., Kalms, J., Rippers, Y., Lendzian, F., Zebger, I., Teutloff, C., Kaupp, M., Bittl, R., Hildebrandt, P., Friedrich, B., Lenz, O., Scheerer, P. 2014. Reversible [4Fe-3S] cluster morphing in an O2-tolerant [NiFe] hydrogenase. Nat Chem Biol. 5:378-85
  • Fritsch, J., E. Siebert, J. Priebe, I. Zebger, F. Lendzian, C. Teutloff, B. Friedrich, and O. Lenz. 2014. Rubredoxin-related maturation factor guarantees metal cofactor integrity during aerobic biosynthesis of membrane-bound [NiFe]-hydrogenase. J Biol Chem. 289:7982-7993
  • Schäfer, C., B. Friedrich, and O. Lenz. 2013. Novel, oxygen-insensitive group 5 [NiFe]-hydrogenase inRalstonia eutropha. Appl Environ Microbiol 79:5137-5145
  • Fritsch, J., O. Lenz, and B. Friedrich. 2013. Structure, function and biosynthesis of O2-tolerant hydrogenases. Nat Rev Microbiol. 11:106-14
  • Schwartz, E., J. Fritsch, and B. Friedrich. 2013. In: The Prokaryotes (Eds.: E. Rosenberg, E. DeLong, S. Lory, E. Stackebrandt, F. Thompson), Springer Berlin Heidelberg, pp. 119-199
  • Lütte, S., A. Pohlmann, E. Zaychikov, E. Schwartz, J. R. Becher, H. Heumann, and B. Friedrich. 2012. Autotrophic production of stable isotope labeled-arginine in Ralstonia eutropha strain H16. Appl Environ Microbiol. 78:7884-7890
  • Bürstel, I., E. Siebert, G. Winter, P. Hummel, I. Zebger, B. Friedrich, and O. Lenz. 2012. A universal scaffold for synthesis of the Fe(CN)2(CO) moiety of [NiFe]-hydrogenase. J Biol Chem. 287:38845-38853
  • Sezer, M., S. Frielingsdorf, D. Millo, N. Heidary, T. Utesch, M.-A. Mroginski, B. Friedrich, P. Hildebrandt, I. Zebger, and I. M. Weidinger. 2011. Role of the HoxZ subunit in the electron transfer pathway of the membrane-bound [NiFe]-hydrogenase from Ralstonia eutropha immobilized on electrodes. J Phys Chem. B 115:10368-10374
  • Poehlein, A., B. Kusian, B. Friedrich, R. Daniel, and B. Bowien. 2011. Complete genome Sequence of the type strain Cupriavidus necator N-1. J Bacteriol. 193:5017
  • Lukey, M. J., M. M. Roessler, A. Parkin, R. M. Evans, R. A. Davies, O. Lenz, B. Friedrich, F. Sargent, and F. A. Armstrong. 2011. Oxygen-tolerant [NiFe]-hydrogenases: the individual and collective importance of supernumerary cysteines at the proximal Fe-S cluster.  J Am Chem Soc. 133:16881-16892
  • Kohlmann, Y., A. Pohlmann, A. Otto, D. Becher, R. Cramm, S. Lütte, E. Schwartz, M. Hecker, and B. Friedrich. 2011. Analyses of soluble and membrane proteomes of Ralstonia eutropha H16 reveal major changes in the protein complement in adaptation to lithoautotrophy. J Proteome Res. 10:2767-2776
  • Goris, T., A. F. Wait, M. Saggu, J. Fritsch, N. Heidary, M. Stein, I. Zebger, F. Lendzian, F. A. Armstrong, B. Friedrich, and O. Lenz. 2011. A unique iron-sulfur cluster is crucial for oxygen tolerance of a [NiFe]-hydrogenase. Nat Chem Biol. 7:310-318
  • Fritsch, J., P. Scheerer, S. Frielingsdorf, S. Kroschinsky, B. Friedrich, O. Lenz, and C. M. Spahn.2011. The crystal structure of an oxygen-tolerant hydrogenase unmasks a novel iron-sulphur centre. Nature479:249-253
  • Fritsch, J., O. Lenz, and B. Friedrich. 2011. The maturation factors HoxR and HoxT contribute to oxygen tolerance of membrane-bound [NiFe]-hydrogenase in Ralstonia eutropha H16. J Bacteriol. 193:2487-2497
  • Fritsch, J., S. Löscher, O. Sanganas, E. Siebert, I. Zebger, M. Stein, M. Ludwig, A. L. D. Lacey, H. Dau, B. Friedrich, O. Lenz, and M. Haumann. 2011. [NiFe]- and [FeS]-cofactors in the membrane-bound hydrogenase of Ralstonia eutropha investigated by X-ray absorption spectroscopy: insights into O2-tolerant H2-cleavage. Biochemistry. 50:5858-5869
  • Friedrich, B., J. Fritsch, and O. Lenz. 2011. Oxygen-tolerant hydrogenases in hydrogen-based technologies. Curr Opin Biotechnol. 22:358-364
  • Bürstel, I., P. Hummel, E. Siebert, N. Wisitruangsakul, I. Zebger, B. Friedrich, and O. Lenz. 2011. Probing the origin of the metabolic precursor of the CO ligand in the catalytic center of [NiFe]-hydrogenase. J Biol Chem 286:44937-44944
  • Winter, G., S. Dökel, A. K. Jones, P. Scheerer, N. Krauss, W. Höhne, and B. Friedrich.  2010. Crystallization and preliminary X-ray crystallographic analysis of the [NiFe] hydrogenase maturation factor HypF1 from Ralstonia eutropha H16. 2010. Acta Cryst. F. 66:452-455
  • Saggu, M., C. Teutloff, M. Ludwig, M. Brecht, M.-E. Pandelia, O. Lenz, B. Friedrich, W. Lubitz, P. Hildebrandt, F. Lendzian, and R. Bittl.  2010. Comparison of the of the membrane-bound [NiFe] hydrogenases from R. eutropha H16 and D. vulgaris Miyazaki F in the oxidized ready state by pulsed EPR. Phys Chem Chem Phys. 12:2139-2148
  • Saggu, M., M. Ludwig, B. Friedrich, P. Hildebrandt, R. Bittl, F. Lendzian, O. Lenz, and I. Zebger.2010. Impact of amino acid substitutions near the catalytic site on the spectral properties of an O2-tolerant membrane-bound [NiFe]-hydrogenase. Chem. Phys. Chem. 11:1215-1224
  • Löscher, S., A. Gebler, M. Stein, O. Sanganas, T. Buhrke, I. Zebger, H. Dau, B. Friedrich, O. Lenz, and M. Haumann. 2010. Protein-protein complex formation affects the Ni-Fe and Fe-S centers in the H2-sensing regulatory hydrogenase from Ralstonia eutropha H16.Chem Phys Chem. 11:1297-1306
  • Lenz, O., M. Ludwig, T. Schubert, I. Bürstel, S. Ganskow, T. Goris, A. Schwarze, and B. Friedrich.2010. H2 conversion in the presence of O2 as performed by the membrane-bound [NiFe]-hydrogenase of Ralstonia eutropha.Chem Phys Chem. 11:1107-1119
  • Friedrich, B. Nature's way to exploit dihydrogen as an alternative fuel. 2010. FEBS J. 277:(Suppl. 1) 12-13
  • Cracknell, J. A., B. Friedrich, and F. A. Armstrong. 2010. Gas pressure effects on the rates of catalytic H2 oxidation by hydrogenases. Chem Commun (Camb). 46:8463-8465
  • Krassen H., A. Schwarze, B. Friedrich, K. Ataka, O. Lenz, and J. Heberle. 2009. Photosynthetic hydrogen production by a hybrid complex of photosystem I and [NiFe]-hydrogenase. ACS Nano 3:4055-4061
  • Schwartz, E., B. Voigt, D. Zühlke, A. Pohlmann, O. Lenz, D. Albrecht, A. Schwarze, Y. Kohlmann, C. Krause, M. Hecker, and B. Friedrich. 2009. A proteomic view of the facultatively chemolithoautotrophic lifestyle of Ralstonia eutropha H16. Proteomics 9:5132-42.  PubMed
  • Saggu, M., I. Zebger, M. Ludwig, O. Lenz, B. Friedrich, P. Hildebrandt, and F. Lendzian. 2009. Spectroscopic insights into the oxygen-tolerant membrane-associated [NiFe] hydrogenase of Ralstonia eutropha H16. J Biol Chem 284:16264-76.  PubMed
  • Cracknell, J. A., A. F. Wait, O. Lenz, B. Friedrich, and F. A. Armstrong. 2009. A Kinetic and thermodynamic understanding of O2 tolerance in [NiFe]-Hydrogenases. Proc Natl Acad Sci USA. 106:20681-6.  PubMed 
  • Cramm, R., and B. Friedrich. 2009. Microbial sensor systems for dihydrogen, nitric oxide, and carbon monoxide. In R. Krämer and K. Jung (ed.), Bacterial signalling. Wiley-VCH, Weinheim.
  • Friedrich, B. 2009. The Role of National Academies of Sciences in Modern Societies, p. 73-79. In M. Djurovi´c (ed.), International Conference "Role of National Science Academies in the 21st Century", vol. 92. Central National Library Cetinje, Montenegro, Podgorica.
  • Friedrich, B. 2009. Wasserstoffaktivierung in Gegenwart von Sauerstoff: Eine Herausforderung für den katalysator Hydrogenase, p. 120-125, Jahrbuch der Braunschweigischen Wissenschaftlichen Gesellschaft 2008. J. Cramer Verlag, Braunschweig.
  • Friedrich, B., and O. Lenz. 2009. Three ways to confer oxygen tolerance to [NiFe]-hydrogenases. J Biol Inorg Chem. 14:5-7. 
  • Ludwig, M., T. Schubert, I. Zebger, N. Wisitruangsakul, M. Saggu, A. Strack, O. Lenz, P. Hildebrandt, and B. Friedrich. 2009. Concerted action of two novel auxiliary proteins in assembly of the active site in a membrane-bound [NiFe]-hydrogenase. J Biol Chem. 284:2159-68.  PubMed
  • Cracknell, J. A., K. A. Vincent, M. Ludwig, O. Lenz, B. Friedrich, and F. A. Armstrong. 2008. Enzymatic oxidation of H2 in atmospheric O2: The electrochemistry of energy generation from trace H2 by aerobic microorganisms. J Am Chem Soc. 130:424-5.  PubMed
  • Goldet, G., A. F. Wait, J. A. Cracknell, K. A. Vincent, M. Ludwig, O. Lenz, B. Friedrich, and F. A. Armstrong. 2008. Hydrogen production under aerobic conditions by membrane-bound hydrogenases fromRalstonia eutropha. J Am Chem Soc. 130:11106-11113.  PubMed
  • Lenz, O., and B. Friedrich. 2008, posting date. Biokatalysatoren für die Erzeugung von Wasserstoff und Strom. Aktuelle Wochenschau der GDCh, Woche 45.  link
  • Raberg, M., F. Reinecke, R. Reichelt, U. Malkus, S. König, M. Pötter, W. F. Fricke, A. Pohlmann, B. Voigt, M. Hecker, B. Friedrich, B. Bowien, and A. Steinbüchel. 2008. Ralstonia eutropha H16 flagellation changes according to nutrient supply and state of poly(3-hydroxybutyrate) accumulation. Appl Environ Microbiol. 74:4477-90.  PubMed 
  • Wisitruangsakul, N., O. Lenz, M. Ludwig, B. Friedrich, F. Lendzian, P. Hildebrandt, and I. Zebger.2008. Monitoring catalysis of the membrane-bound hydrogenase from Ralstonia eutropha H16 by surface-enhanced infrared absorption spectroscopy. Angew Chem Int Ed Engl. 48:611-613.  PubMed 
  • Gebler, A., T. Burgdorf, A. L. De Lacey, O. Rüdiger, A. Martinez-Arias, O. Lenz, and B. Friedrich.2007. Impact of alterations near the [NiFe] active site on the function of the H2 sensor from Ralstonia eutropha. FEBS J. 274:74-85.  PubMed
  • Lenz, O., I. Zebger, J. Hamann, P. Hildebrandt, and B. Friedrich. 2007. Carbamoylphosphate serves as the source of CN-, but not of the intrinsic CO in the active site of the regulatory [NiFe]-hydrogenase fromRalstonia eutropha. FEBS Lett. 581:3322-6.  PubMed 
  • Schubert, T., O. Lenz, E. Krause, R. Volkmer, and B. Friedrich. 2007. Chaperones specific for the membrane-bound [NiFe]-hydrogenase interact with the Tat signal peptide of the small subunit precursor inRalstonia eutropha H16. Mol Microbiol.  66 453-467.  PubMed 
  • Löscher, S., T. Burgdorf, I. Zebger, P. Hildebrandt, H. Dau, B. Friedrich, and M. Haumann. 2006. Bias from H2 cleavage to production and coordination changes at the Ni-Fe active site in the NAD+-reducing hydrogenase from Ralstonia eutropha. Biochemistry. 45:11658-65.  PubMed
  • Pohlmann, A., W. F. Fricke, F. Reinecke, B. Kusian, H. Liesegang, R. Cramm, T. Eitinger, C. Ewering, M. Pötter, E. Schwartz, A. Strittmatter, I. Voss, G. Gottschalk, A. Steinbüchel, B. Friedrich, and B. Bowien. 2006. Genome sequence of the bioplastic-producing "Knallgas" bacterium Ralstonia eutropha H16. Nat Biotechnol. 24:1257-62.  PubMed
  • Ihara, M., H. Nishihara, K. S. Yoon, O. Lenz, B. Friedrich, H. Nakamoto, K. Kojima, D. Honma, T. Kamachi, and I. Okura. 2006. Light-driven hydrogen production by a hybrid complex of a [NiFe]-hydrogenase and the cyanobacterial photosystem I. Photochem Photobiol. 82:676-82.  PubMed
  • Van der Linden, E., T. Burgdorf, A. L. de Lacey, T. Buhrke, M. Scholte, V. M. Fernandez, B. Friedrich, and S. P. Albracht. 2006. An improved purification procedure for the soluble [NiFe]-hydrogenase ofRalstonia eutropha: new insights into its (in)stability and spectroscopic properties. J Biol Inorg Chem.11:247-60.  PubMed
  • Vincent, K. A., J. A. Cracknell, J. R. Clark, M. Ludwig, O. Lenz, B. Friedrich, and F. A. Armstrong.2006. Electricity from low-level H2 in still air - an ultimate test for an oxygen tolerant hydrogenase. Chem Commun (Camb). 48:5033-5.  PubMed
  • Pohlmann, A., W. F. Fricke, F. Reinecke, B. Kusian, H. Liesegang, R. Cramm, T. Eitinger, C. Ewering, M. Pötter, E. Schwartz, A. Strittmatter, I. Voss, G. Gottschalk, A. Steinbüchel, B. Friedrich, and B. Bowien. 2006. Ralstonia eutropha H16: Genom eines Bioplastik produzierenden Knallgasbakteriums. GenomXpress 4:7-8. 
  • Schwartz, E., and B. Friedrich. 2006. The H2-metabolizing prokaryotes. In M. Dworkin, S. Falkow, E. Rosenberg, K. H. Schleifer, and E. Stackebrandt (ed.), The prokaryotes. A handbook on the biology of bacteria, 3rd ed. Springer, New York.
  • Lenz, O., A. Gleiche, A. Strack, and B. Friedrich. 2005. Requirements for heterologous production of a complex metalloenzyme: the membrane-bound [NiFe] hydrogenase. J Bacteriol. 187:6590-5.  PubMed
  • Vincent, K. A., J. A. Cracknell, O. Lenz, I. Zebger, B. Friedrich, and F. A. Armstrong. 2005. Electrocatalytic hydrogen oxidation by an enzyme at high carbon monoxide or oxygen levels. Proc Natl Acad Sci USA. 102:16951-4.  PubMed
  • Buhrke, T., S. Löscher, O. Lenz, E. Schlodder, I. Zebger, L. K. Andersen, P. Hildebrandt, W. Meyer-Klaucke, H. Dau, B. Friedrich, and M. Haumann. 2005. Reduction of unusual iron-sulfur clusters in the H2-sensing regulatory Ni-Fe hydrogenase from Ralstonia eutropha H16. J Biol Chem. 280:19488-95.  PubMed
  • Burgdorf, T., E. van der Linden, M. Bernhard, Q. Y. Yin, J. W. Back, A. F. Hartog, A. O. Muijsers, C. G. de Koster, S. P. Albracht, and B. Friedrich. 2005. The Soluble NAD+-Reducing [NiFe]-Hydrogenase from Ralstonia eutropha H16 Consists of Six Subunits and Can Be Specifically Activated by NADPH. J Bacteriol.187:3122-32.  PubMed
  • Burgdorf, T., S. Löscher, P. Liebisch, E. Van der Linden, M. Galander, F. Lendzian, W. Meyer-Klaucke, S. P. Albracht, B. Friedrich, H. Dau, and M. Haumann. 2005. Structural and oxidation-state changes at its nonstandard Ni-Fe site during activation of the NAD-reducing hydrogenase from Ralstonia eutropha detected by X-ray absorption, EPR, and FTIR spectroscopy. J Am Chem Soc. 127:576-92.  PubMed
  • Büsch, A., K. Strube, B. Friedrich, and R. Cramm. 2005. Transcriptional regulation of nitric oxide reduction in Ralstonia eutropha H16. Biochem Soc Trans. 33:193-4.  PubMed
  • Friedrich, B., T. Buhrke, T. Burgdorf, and O. Lenz. 2005. A hydrogen-sensing multiprotein complex controls aerobic hydrogen metabolism in Ralstonia eutropha. Biochem Soc Trans. 33:97-101.  PubMed
  • Vincent, K. A., A. Parkin, O. Lenz, S. P. Albracht, J. C. Fontecilla-Camps, R. Cammack, B. Friedrich, and F. A. Armstrong. 2005. Electrochemical definitions of O2 sensitivity and oxidative inactivation in hydrogenases. J Am Chem Soc. 127:18179-89.  PubMed
  • Lutz, B. J., Z. H. Fan, T. Burgdorf, and B. Friedrich. 2005. Hydrogen sensing by enzyme-catalyzed electrochemical detection. Anal Chem. 77:4969-75.  PubMed
  • Buhrke, T., O. Lenz, N. Krauss, and B. Friedrich. 2005. Oxygen tolerance of the H2-sensing [NiFe] hydrogenase from Ralstonia eutropha H16 is based on limited access of oxygen to the active site. J Biol Chem.280:23791-6.  PubMed
  • Burgdorf, T., O. Lenz, T. Buhrke, E. van der Linden, A. K. Jones, S. P. Albracht, and B. Friedrich.2005. [NiFe]-hydrogenases of Ralstonia eutropha H16: modular enzymes for oxygen-tolerant biological hydrogen oxidation. J Mol Microbiol Biotechnol. 10:181-96.  PubMed
  • Friedrich, B. 2005. Energiewandlung bei Mikroorganismen: Wasserstoff, eine begehrte Nahrungsquelle, p. 89-105. In H. Fritzsch (ed.), Materie in Raum und Zeit. S. Hirtzel Verlag, Stuttgart.
  • Hacker, J., and B. Friedrich. 2005. Das neue Gesetz zur "Grünen Gentechnik" - Zu unserem Umgang mit einer Schlüsseltechnologie des 21. Jahrhunderts. BIOspektrum 2:184-187. 
  • Löscher, S., T. Burgdorf, T. Buhrke, B. Friedrich, H. Dau, and M. Haumann. 2005. Non-standard structures of the Ni-Fe cofactor in the regulatory and the NAD-reducing hydrogenases from Ralstonia eutropha. Biochem Soc Trans. 33:25-7.  PubMed
  • Winter, G., T. Buhrke, O. Lenz, A. K. Jones, M. Forgber, and B. Friedrich. 2005. A model system for [NiFe] hydrogenase maturation studies: Purification of an active site-containing hydrogenase large subunit without small subunit. FEBS Lett. 579:4292-6.  PubMed
  • Van der Linden, E., T. Burgdorf, M. Bernhard, B. Bleijlevens, B. Friedrich, and S. P. Albracht. 2004. The soluble [NiFe]-hydrogenase from Ralstonia eutropha contains four cyanides in its active site, one of which is responsible for the insensitivity towards oxygen. J Biol Inorg Chem. 9:616-26.  PubMed
  • Van der Linden, E., B. W. Faber, B. Bleijlevens, T. Burgdorf, M. Bernhard, B. Friedrich, and S. P. Albracht. 2004. Selective release and function of one of the two FMN groups in the cytoplasmic NAD+-reducing [NiFe]-hydrogenase from Ralstonia eutropha. Eur J Biochem. 271:801-8.  PubMed
  • Büsch, A., A. Pohlmann, B. Friedrich, and R. Cramm. 2004. A DNA region recognized by the nitric oxide-responsive transcriptional activator NorR is conserved in beta- and gamma-proteobacteria. J Bacteriol.186:7980-7.  PubMed
  • Bleijlevens, B., T. Buhrke, E. van der Linden, B. Friedrich, and S. P. Albracht. 2004. The auxiliary protein HypX provides oxygen tolerance to the soluble [NiFe]-hydrogenase of Ralstonia eutropha H16 by way of a cyanide ligand to nickel. J Biol Chem. 279:46686-91.  PubMed
  • Buhrke, T., O. Lenz, A. Porthun, and B. Friedrich. 2004. The H2-sensing complex of Ralstonia eutropha: interaction between a regulatory [NiFe] hydrogenase and a histidine protein kinase. Mol Microbiol. 51:1677-89.  PubMed
  • Jones, A. K., O. Lenz, A. Strack, T. Buhrke, and B. Friedrich. 2004. NiFe hydrogenase active site biosynthesis: identification of Hyp protein complexes in Ralstonia eutropha. Biochemistry. 43:13467-77. PubMed
  • Pötter, M., H. Müller, F. Reinecke, R. Wieczorek, F. Fricke, B. Bowien, B. Friedrich, and A. Steinbüchel. 2004. The complex structure of polyhydroxybutyrate (PHB) granules: four orthologous and paralogous phasins occur in Ralstonia eutropha. Microbiology. 150:2301-11.  PubMed
  • Steinbüchel, A., B. Bowien, and B. Friedrich. 2004. Ralstonia eutropha Stamm H16 - eine potentielle Zellfabrik. GenomXpress 4.04:13-14. 
  • Winter, G., T. Buhrke, A. K. Jones, and B. Friedrich. 2004. The role of the active site-coordinating cysteine residues in the maturation of the H2-sensing [NiFe] hydrogenase from Ralstonia eutropha H16. Arch Microbiol. 182:138-46.  PubMed
  • Haumann, M., A. Porthun, T. Buhrke, P. Liebisch, W. Meyer-Klaucke, B. Friedrich, and H. Dau. 2003. Hydrogen-induced structural changes at the nickel site of the regulatory [NiFe] hydrogenase from Ralstonia eutropha detected by X-ray absorption spectroscopy. Biochemistry. 42:11004-15.  PubMed
  • Schwartz, E., A. Henne, R. Cramm, T. Eitinger, B. Friedrich, and G. Gottschalk. 2003. Complete nucleotide sequence of pHG1: a Ralstonia eutropha H16 megaplasmid encoding key enzymes of H2-based lithoautotrophy and anaerobiosis. J Mol Biol. 332:369-83.  PubMed
  • Brecht, M., M. van Gastel, T. Buhrke, B. Friedrich, and W. Lubitz. 2003. Direct detection of a hydrogen ligand in the [NiFe] center of the regulatory H2-sensing hydrogenase from Ralstonia eutropha in its reduced state by HYSCORE and ENDOR spectroscopy. J Am Chem Soc. 125:13075-83.  PubMed
  • Friedrich, B. 2003. Regulatory networks in prokaryotes: variations on a theme, p. 1-3. In P. Dürre and B. Friedrich (ed.), Regulatory networks in prokaryotes. Horizon Scientific Press.
  • Friedrich, B., O. Lenz, T. Burgdorf, and T. Buhrke. 2003. [NiFe] hydrogenases under aerobic conditions. J Inorg Biochem. 96:46. 
  • Lenz, O., M. Bernhard, T. Buhrke, E. Schwartz, and B. Friedrich. 2003. The hydrogen-sensing apparatus in Ralstonia eutropha, p. 85-92. In P. Dürre and B. Friedrich (ed.), Regulatory networks in prokaryotes. Horizon Scientific Press, Wymondham, England.
  • Schwartz, E., and B. Friedrich. 2003. The H2-metabolizing prokaryotes. In M. Dworkin, S. Falkow, E. Rosenberg, K. H. Schleifer, and E. Stackebrandt (ed.), The prokaryotes: an evolving electronic resource for the microbiological community, Release 3.14, 3rd ed. Springer, New York.
  • Burgdorf, T., A. L. De Lacey, and B. Friedrich. 2002. Functional analysis by site-directed mutagenesis of the NAD+-reducing hydrogenase from Ralstonia eutropha. J Bacteriol. 184:6280-8.  PubMed
  • Friedrich, B. 2002. Regulatory networks in prokaryotes: variations on a theme. J Mol Microbiol Biotechnol.4:171-3.  PubMed
  • Lenz, O., M. Bernhard, T. Buhrke, E. Schwartz, and B. Friedrich. 2002. The hydrogen-sensing apparatus in Ralstonia eutropha. J Mol Microbiol Biotechnol. 4:255-62.  PubMed
  • Buhrke, T., M. Brecht, W. Lubitz, and B. Friedrich. 2002. The H2 sensor of Ralstonia eutropha: biochemical and spectroscopic analysis of mutant proteins modified at a conserved glutamine residue close to the [NiFe] active site. J Biol Inorg Chem. 7:897-908.  PubMed
  • Büsch, A., B. Friedrich, and R. Cramm. 2002. Characterization of the norB gene, encoding nitric oxide reductase, in the nondenitrifying cyanobacterium Synechocystis sp. strain PCC6803. Appl Environ Microbiol.68:668-72.  PubMed
  • Lubitz, W., M. Brecht, S. Foerster, M. Stein, Y. Higuchi, T. Buhrke, and B. Friedrich. 2002. EPR and theoretical investigations of [NiFe] hydrogenase: insights into the mechanism of biological hydrogen conversion, p. 437-445. In A. Kawamori, J. Yamauchi, and H. Ohta (ed.), EPR in the 21st century. Elsevier Science, Amsterdam.
  • Porthun, A., M. Bernhard, and B. Friedrich. 2002. Expression of a functional NAD-reducing [NiFe] hydrogenase from the gram-positive Rhodococcus opacus in the gram-negative Ralstonia eutropha. Arch Microbiol. 177:159-66.  PubMed
  • Bernhard, M., T. Buhrke, B. Bleijlevens, A. L. De Lacey, V. M. Fernandez, S. P. Albracht, and B. Friedrich. 2001. The H2 sensor of Ralstonia eutropha. Biochemical characteristics, spectroscopic properties, and its interaction with a histidine protein kinase. J Biol Chem. 276:15592-7.  PubMed
  • Schwartz, E., and B. Friedrich. 2001. A physical map of the megaplasmid pHG1, one of three genomic replicons in Ralstonia eutropha H16. FEMS Microbiol Lett. 201:213-9.  PubMed
  • Buhrke, T., B. Bleijlevens, S. P. Albracht, and B. Friedrich. 2001. Involvement of hyp gene products in maturation of the H2-sensing [NiFe] hydrogenase of Ralstonia eutropha. J Bacteriol. 183:7087-93.  PubMed
  • Nishihara, H., Y. Miyata, Y. Miyashita, M. Bernhard, A. Pohlmann, B. Friedrich, and Y. Takamura.2001. Analysis of the molecular species of hydrogenase in the cells of an obligately chemolithoautotrophic, marine hydrogen-oxidizing bacterium, Hydrogenovibrio marinus. Biosci Biotechnol Biochem. 65:2780-4. PubMed
  • Friedrich, B., P. M. Vignais, O. Lenz, and A. Colbeau. 2001. Regulation of hydrogenase gene expression, p. 73-92. In R. Cammack, M. Frey, and R. Robson (ed.), Hydrogen as a fuel. Taylor & Francis, London.
  • Lenz, O., and B. Friedrich. 2001. Bakterielle Wasserstoff-Sensoren. BIOspektrum 6:515-20. 
  • Pohlmann, A., R. Cramm, K. Schmelz, and B. Friedrich. 2000. A novel NO-responding regulator controls the reduction of nitric oxide in Ralstonia eutropha. Mol Microbiol. 38:626-38.  PubMed
  • Kleihues, L., O. Lenz, M. Bernhard, T. Buhrke, and B. Friedrich. 2000. The H2 sensor of Ralstonia eutropha is a member of the subclass of regulatory [NiFe] hydrogenases. J Bacteriol. 182:2716-24.  PubMed
  • Happe, R. P., W. Roseboom, G. Egert, C. G. Friedrich, C. Massanz, B. Friedrich, and S. P. Albracht.2000. Unusual FTIR and EPR properties of the H2-activating site of the cytoplasmic NAD-reducing hydrogenase from Ralstonia eutropha. FEBS Lett. 466:259-63.  PubMed
  • Bernhard, M., B. Friedrich, and R. A. Siddiqui. 2000. Ralstonia eutropha TF93 is blocked in tat-mediated protein export. J Bacteriol. 182:581-8.  PubMed
  • Schwartz, E., T. Buhrke, U. Gerischer, and B. Friedrich. 1999. Positive transcriptional feedback controls hydrogenase expression in Alcaligenes eutrophus H16. J Bacteriol. 181:5684-92.  PubMed
  • Massanz, C., and B. Friedrich. 1999. Amino acid replacements at the H2-activating site of the NAD-reducing hydrogenase from Alcaligenes eutrophus. Biochemistry. 38:14330-7.  PubMed
  • Cramm, R., A. Pohlmann, and B. Friedrich. 1999. Purification and characterization of the single-component nitric oxide reductase from Ralstonia eutropha H16. FEBS Lett. 460:6-10.  PubMed
  • Siedow, A., R. Cramm, R. A. Siddiqui, and B. Friedrich. 1999. A megaplasmid-borne anaerobic ribonucleotide reductase in Alcaligenes eutrophus H16. J Bacteriol. 181:4919-28.  PubMed
  • Lenz, O., and B. Friedrich. 1998. A novel multicomponent regulatory system mediates H2 sensing inAlcaligenes eutrophus. Proc Natl Acad Sci USA. 95:12474-9.  PubMed
  • Pierik, A. J., M. Schmelz, O. Lenz, B. Friedrich, and S. P. Albracht. 1998. Characterization of the active site of a hydrogen sensor from Alcaligenes eutrophus. FEBS Lett. 438:231-5.  PubMed
  • Massanz, C., S. Schmidt, and B. Friedrich. 1998. Subforms and in vitro reconstitution of the NAD-reducing hydrogenase of Alcaligenes eutrophus. J Bacteriol. 180:1023-9.  PubMed
  • Schwartz, E., U. Gerischer, and B. Friedrich. 1998. Transcriptional regulation of Alcaligenes eutrophushydrogenase genes. J Bacteriol. 180:3197-204.  PubMed
  • Buhrke, T., and B. Friedrich. 1998. hoxX (hypX) is a functional member of the Alcaligenes eutrophus hypgene cluster. Arch Microbiol. 170:460-3.  PubMed
  • Friedrich, B. 1998. Ein Leben mit molekularem Wasserstoff 43. Jahrbuch der LEOPOLDINA (R3).
  • Lieb, C., R. A. Siddiqui, B. Hippler, D. Jahn, and B. Friedrich. 1998. The Alcaligenes eutrophus hemNgene encoding the oxygen-independent coproporphyrinogen III oxidase, is required for heme biosynthesis during anaerobic growth. Arch Microbiol. 169:52-60.  PubMed
  • Wolf, I., T. Buhrke, J. Dernedde, A. Pohlmann, and B. Friedrich. 1998. Duplication of hyp genes involved in maturation of [NiFe] hydrogenases in Alcaligenes eutrophus H16. Arch Microbiol. 170:451-9. PubMed
  • Cramm, R., R. A. Siddiqui, and B. Friedrich. 1997. Two isofunctional nitric oxide reductases in Alcaligenes eutrophus H16. J Bacteriol. 179:6769-77.  PubMed
  • Lenz, O., A. Strack, A. Tran-Betcke, and B. Friedrich. 1997. A hydrogen-sensing system in transcriptional regulation of hydrogenase gene expression in Alcaligenes species. J Bacteriol. 179:1655-63.  PubMed
  • Rees, E., R. A. Siddiqui, F. Köster, B. Schneider, and B. Friedrich. 1997. Structural gene (nirS) for the cytochrome cd1 nitrite reductase of Alcaligenes eutrophus H16. Appl Environ Microbiol. 63:800-2.  PubMed
  • Bernhard, M., B. Benelli, A. Hochkoeppler, D. Zannoni, and B. Friedrich. 1997. Functional and structural role of the cytochrome b subunit of the membrane-bound hydrogenase complex of Alcaligenes eutrophus H16. Eur J Biochem. 248:179-86.  PubMed
  • Eitinger, T., and B. Friedrich. 1997. Microbial nickel transport and incorporation into hydrogenases, p. 235-256. In G. Winkelmann and C. Carrano (ed.), Transition Metals in Microbial Metabolism. Harwood Academic Publishers, Amsterdam.
  • Eitinger, T., L. Wolfram, J. Dernedde, I. Wolf, N. Patenge, and B. Friedrich. 1997. Nickel metabolism inAlcaligenes eutrophus: uptake by a Ni2+-specific permease and metal insertion into the hydrogenases, p. 37-50. In A. X. Trautwein (ed.), Deutsche Forschungsgemeinschaft, bioinorganic chemistry, transition metals in biology and their coordination chemistry. Wiley-VCH, Weinheim.
  • Friedrich, B. 1997. Wasserstoff: Eine früh verfügbare Energiequelle der biochemischen Evolution, p. 9-22, Berlin-Brandenburgische Akademie der Wissenschaften, Berichte & Abhandlungen, vol. 4. Akademie Verlag, Berlin.
  • Massanz, C., V. M. Fernandez, and B. Friedrich. 1997. C-terminal extension of the H2-activating subunit, HoxH, directs maturation of the NAD-reducing hydrogenase in Alcaligenes eutrophus. Eur J Biochem.245:441-8.  PubMed
  • Hole, U. H., K. U. Vollack, W. G. Zumft, E. Eisenmann, R. A. Siddiqui, B. Friedrich, and P. M. Kroneck. 1996. Characterization of the membranous denitrification enzymes nitrite reductase (cytochromecd1) and copper-containing nitrous oxide reductase from Thiobacillus denitrificans. Arch Microbiol. 165:55-61.  PubMed
  • Thiemermann, S., J. Dernedde, M. Bernhard, W. Schroeder, C. Massanz, and B. Friedrich. 1996. Carboxyl-terminal processing of the cytoplasmic NAD-reducing hydrogenase of Alcaligenes eutrophus requires the hoxW gene product. J Bacteriol. 178:2368-74.  PubMed
  • Bernhard, M., E. Schwartz, J. Rietdorf, and B. Friedrich. 1996. The Alcaligenes eutrophus membrane-bound hydrogenase gene locus encodes functions involved in maturation and electron transport coupling. J Bacteriol. 178:4522-9.  PubMed
  • Dernedde, J., T. Eitinger, N. Patenge, and B. Friedrich. 1996. hyp gene products in Alcaligenes eutrophus are part of a hydrogenase-maturation system. Eur J Biochem. 235:351-8.  PubMed
  • Friedrich, B., M. Bernhard, J. Dernedde, T. Eitinger, O. Lenz, C. Massanz, and E. Schwartz. 1996. Hydrogen oxidation by Alcaligenes eutrophus, p. 110-117. In M. E. Lidstrom and F. R. Tabita (ed.), Microbial Growth on C1 Compounds. Kluwer Academic Publishers, Dordrecht, The Netherlands.
  • Ermler, U., R. A. Siddiqui, R. Cramm, and B. Friedrich. 1995. Crystal structure of the flavohemoglobin from Alcaligenes eutrophus at 1.75 Å resolution. Embo J. 14:6067-77.  PubMed
  • Ermler, U., R. A. Siddiqui, R. Cramm, D. Schröder, and B. Friedrich. 1995. Crystallization and preliminary X-ray diffraction studies of a bacterial flavohemoglobin protein. Proteins. 21:351-3.  PubMed
  • Eitinger, T., L. Wolfram, and B. Friedrich. 1995. Molecular characterization of the Alcaligenes eutrophusnickel permease J Inorg Biochem. 59:644. 
  • Wolfram, L., B. Friedrich, and T. Eitinger. 1995. The Alcaligenes eutrophus protein HoxN mediates nickel transport in Escherichia coli. J Bacteriol. 177:1840-3.  PubMed
  • Zimmer, D., E. Schwartz, A. Tran-Betcke, P. Gewinner, and B. Friedrich. 1995. Temperature tolerance of hydrogenase expression in Alcaligenes eutrophus is conferred by a single amino acid exchange in the transcriptional activator HoxA. J Bacteriol. 177:2373-80.  PubMed
  • Cramm, R., R. A. Siddiqui, and B. Friedrich. 1994. Primary sequence and evidence for a physiological function of the flavohemoprotein of Alcaligenes eutrophus. J Biol Chem. 269:7349-54.  PubMed
  • Lenz, O., E. Schwartz, J. Dernedde, M. Eitinger, and B. Friedrich. 1994. The Alcaligenes eutrophus H16hoxX gene participates in hydrogenase regulation. J Bacteriol. 176:4385-93.  PubMed
  • Eitinger, T., and B. Friedrich. 1994. A topological model for the high-affinity nickel transporter ofAlcaligenes eutrophus. Mol Microbiol. 12:1025-32.  PubMed
  • Sann, R., S. Kostka, and B. Friedrich. 1994. A cytochrome cd1-type nitrite reductase mediates the first step of denitrification in Alcaligenes eutrophus. Arch Microbiol. 161:453-9.  PubMed
  • Siddiqui, R. A., U. Warnecke-Eberz, A. Hengsberger, B. Schneider, S. Kostka, and B. Friedrich. 1993. Structure and function of a periplasmic nitrate reductase in Alcaligenes eutrophus H16. J Bacteriol. 175:5867-76.  PubMed
  • Dernedde, J., M. Eitinger, and B. Friedrich. 1993. Analysis of a pleiotropic gene region involved in formation of catalytically active hydrogenases in Alcaligenes eutrophus H16. Arch Microbiol. 159:545-53. PubMed
  • Friedrich, B., and E. Schwartz. 1993. Molecular biology of hydrogen utilization in aerobic chemolithotrophs. Annu Rev Microbiol. 47:351-83.  PubMed
  • Warnecke-Eberz, U., and B. Friedrich. 1993. Three nitrate reductase activities in Alcaligenes eutrophus. Arch Microbiol. 159:405-409. 
  • Kömen, R., K. Schmidt, and B. Friedrich. 1992. Hydrogenase mutants of Alcaligenes eutrophus H16 show alterations in the electron transport system. FEMS Microbiol Lett. 75:173-8.  PubMed
  • Kortlüke, C., and B. Friedrich. 1992. Maturation of membrane-bound hydrogenase of Alcaligenes eutrophusH16. J Bacteriol. 174:6290-3.  PubMed
  • Kortlüke, C., K. Horstmann, E. Schwartz, M. Rohde, R. Binsack, and B. Friedrich. 1992. A gene complex coding for the membrane-bound hydrogenase of Alcaligenes eutrophus H16. J Bacteriol. 174:6277-89.  PubMed
  • Rensing, C., U. Kues, U. Stahl, D. H. Nies, and B. Friedrich. 1992. Expression of bacterial mercuric ion reductase in Saccharomyces cerevisiae. J Bacteriol. 174:1288-92.  PubMed
  • Warrelmann, J., M. Eitinger, E. Schwartz, D. Römermann, and B. Friedrich. 1992. Nucleotide sequence of the rpoN (hno) gene region of Alcaligenes eutrophus: evidence for a conserved gene cluster. Arch Microbiol. 158:107-14.  PubMed
  • Zumft, W. G., A. Dreusch, S. Löchelt, H. Cuypers, B. Friedrich, and B. Schneider. 1992. Derived amino acid sequences of the nosZ gene (respiratory N2O reductase) from Alcaligenes eutrophusPseudomonas aeruginosa and Pseudomonas stutzeri reveal potential copper-binding residues. Implications for the CuA site of N2O reductase and cytochrome-c oxidase. Eur J Biochem. 208:31-40.  PubMed
  • Dressler, C., U. Kues, D. H. Nies, and B. Friedrich. 1991. Determinants Encoding Resistance to Several Heavy Metals in Newly Isolated Copper-Resistant Bacteria. Appl Environ Microbiol. 57:3079-3085.  PubMed
  • Hanski, C., M. Naumann, A. Grutzkau, G. Pluschke, B. Friedrich, H. Hahn, and E. O. Riecken. 1991. Humoral and cellular defense against intestinal murine infection with Yersinia enterocolitica. Infect Immun.59:1106-11. 
  • Eberz, G., and B. Friedrich. 1991. Three trans-acting regulatory functions control hydrogenase synthesis inAlcaligenes eutrophus. J Bacteriol. 173:1845-54.  PubMed
  • Eitinger, T., and B. Friedrich. 1991. Cloning, nucleotide sequence, and heterologous expression of a high-affinity nickel transport gene from Alcaligenes eutrophus. J Biol Chem. 266:3222-7.  PubMed
  • Wolfram, L., T. Eitinger, and B. Friedrich. 1991. Construction and properties of a triprotein containing the high-affinity nickel transporter of Alcaligenes eutrophus. FEBS Lett. 283:109-12.  PubMed
  • Hornhardt, S., K. Schneider, B. Friedrich, B. Vogt, and H. G. Schlegel. 1990. Identification of distinct NAD-linked hydrogenase protein species in mutants and nickel-deficient wild-type cells of Alcaligenes eutrophus H16. Eur J Biochem. 189:529-37.  PubMed
  • Tran-Betcke, A., U. Warnecke, C. Böcker, C. Zaborosch, and B. Friedrich. 1990. Cloning and nucleotide sequences of the genes for the subunits of NAD-reducing hydrogenase of Alcaligenes eutrophus H16. J Bacteriol. 172:2920-9.  PubMed
  • Bender, R. A., and B. Friedrich. 1990. Regulation of assimilatory nitrate reductase formation in Klebsiella aerogenes W70. J Bacteriol. 172:7256-9.  PubMed
  • Friedrich, B. 1990. The plasmid-encoded hydrogenase gene cluster in Alcaligenes eutrophus. FEMS Microbiol Rev. 87:425-430.
  • Friedrich, B., C. Böcker, G. Eberz, T. Eitinger, K. Horstmann, C. Kortlüke, D. Römermann, E. Schwartz, A. Tran-Betcke, U. Warnecke, and J. Warrelmann. 1990. Genes for hydrogen oxidation and denitrification form two clusters on megaplasmid pHG1 of Alcaligenes eutrophus, p. 408-419. In S. Silver (ed.), Pseudomonas: Biotransformations, Pathogenesis and Evolving Biotechnology. American Society for Microbiology, Washington, DC.
  • Friedrich, B., and C. G. Friedrich. 1990. Hydrogenases in lithoautotrophic bacteria, p. 55-92. In G. A. Codd, L. Dijkhuizen, and F. R. Tabita (ed.), Advances in autotrophic microbiology and one carbon-metabolism. Kluwer Academic Publishers, Dordrecht, The Netherlands.
  • Friedrich, B., U. Warnecke, R. Sann, and B. Schneider. 1990. Presented at the 5th European Congress on Biotechnology, Copenhagen.
  • Fiebig, K., and B. Friedrich. 1989. Purification of the F420-reducing hydrogenase from Methanosarcina barkeri (strain Fusaro). Eur J Biochem. 184:79-88.  PubMed
  • Römermann, D., J. Warrelmann, R. A. Bender, and B. Friedrich. 1989. An rpoN-like gene of Alcaligenes eutrophus and Pseudomonas facilis controls expression of diverse metabolic pathways, including hydrogen oxidation. J Bacteriol. 171:1093-9.  PubMed
  • Eberz, G., T. Eitinger, and B. Friedrich. 1989. Genetic determinants of a nickel-specific transport system are part of the plasmid-encoded hydrogenase gene cluster in Alcaligenes eutrophus. J Bacteriol. 171:1340-5. PubMed
  • Friedrich, B. 1989. Genetics of energy converting systems in aerobic chemolithotrophs, p. 415-436. In H. G. Schlegel and B. Bowien (ed.), Biology of autotrophic bacteria. Science Tech Publishers/Heidelberg, Madison/Heidelberg.
  • Warrelmann, J., and B. Friedrich. 1989. Genetic transfer of lithoautotrophy mediated by a plasmid-cointegrate from Pseudomonas facilis. Arch Microbiol. 151:359-364. 
  • Warrelmann, J., and B. Friedrich. 1989. Large plasmids in wild type strains of Pseudomonas  facilis. Endocytobiosis and Cell Res. 2:213-217. 
  • Weihs, V., K. Schmidt, B. Schneider, and B. Friedrich. 1989. The formation of an oxygen-binding flavohemoprotein in Alcaligenes eutrophus  is plasmid-determined. Arch Microbiol. 151:546-550. 
  • Schneider, B., A. Nies, and B. Friedrich. 1988. Transfer and expression of lithoautotrophy and denitrification in a host lacking these metabolic activities. Appl Environ Microbiol. 54:3173-3176.  PubMed
  • Römermann, D., M. Lohmeyer, C. G. Friedrich, and B. Friedrich. 1988. Pleiotropic mutants fromAlcaligenes eutrophus  defective in the metabolism of hydrogen, nitrate, urea and fumarate. Arch Microbiol.149:471-475. 
  • Nies, D., M. Mergeay, B. Friedrich, and H. G. Schlegel. 1987. Cloning of plasmid genes encoding resistance to cadmium, zinc, and cobalt in Alcaligenes eutrophus CH34. J Bacteriol. 169:4865-8.  PubMed
  • Friedrich, B. 1987. Genetics of aerobic lithoautotrophs, p. 230-237. In H. W. Van Verseveld and J. A. Duine (ed.), Microbial Growth on C1 compounds. Nijhoff Publishers, Dordrecht, The Netherlands.
  • Friedrich, B. 1987. Gentechnologie: Mikroorganismen als Werkzeuge im Dienst des Menschen, p. 73-94. InC. Niemitz (ed.), Erbe und Umwelt - Zur Natur von Anlage und Selbstbestimmung des Menschen, vol. 646. Suhrkamp Taschenbuch Wissenschaft, Frankfurt a. M.
  • Kortlüke, C., C. Hogrefe, G. Eberz, A. Pühler, and B. Friedrich. 1987. Genes of lithoautotrophic metabolism are clustered on the megaplasmid pHG1 in Alcaligenes eutrophus. Mol Gen Genet. 210:122-128. 
  • Eberz, G., C. Hogrefe, C. Kortlüke, A. Kamienski, and B. Friedrich. 1986. Molecular cloning of structural and regulatory hydrogenase (hox) genes of Alcaligenes eutrophus H16. J Bacteriol. 168:636-41.  PubMed
  • Friedrich, B., C. Kortlüke, C. Hogrefe, G. Eberz, B. Silber, and J. Warrelmann. 1986. Genetics of hydrogenase from aerobic lithoautotrophic bacteria. Biochimie. 68:133-45.  PubMed
  • Warrelmann, J., and B. Friedrich. 1986. Mutants of Pseudomonas facilis  defective in lithoautotrophy. J Gen Microbiol. 132:91-96. 
  • Römermann, D., and B. Friedrich. 1985. Denitrification by Alcaligenes eutrophus is plasmid dependent. J Bacteriol. 162:852-4.  PubMed
  • Friedrich, B. 1985. Evolution of chemolithoautotrophy, p. 205-234. In K. H. Schleifer and E. Stackebrandt (ed.), Evolution of Prokaryotes. Academic Press, London.
  • Friedrich, B. 1985. Unkonventionelle Stoffwechselwege in Bakterien werden durch Riesenplasmide kodiert. Sitzungsberichte der Gesellschaft Naturforschender Freunde zu Berlin. p. 127-144.
  • Hogrefe, C., and B. Friedrich. 1984. Isolation and characterization of megaplasmid DNA from lithoautotrophic bacteria. Plasmid. 12:161-9.  PubMed
  • Friedrich, B., C. G. Friedrich, M. Meyer, and H. G. Schlegel. 1984. Expression of hydrogenase inAlcaligenes spp. is altered by interspecific plasmid exchange. J Bacteriol. 158:331-3.  PubMed
  • Hogrefe, C., D. Römermann, and B. Friedrich. 1984. Alcaligenes eutrophus hydrogenase genes (hox). J Bacteriol. 158:43-8.  PubMed
  • Bowien, B., B. Friedrich, and C. G. Friedrich. 1984. Involvement of megaplasmids in heterotrophic derepression of the carbon-dioxide assimilating enzyme system in Alcaligenes spp. Arch Mikrobiol. 139:305-310. 
  • Friedrich, B., and C. Hogrefe. 1984. Genetics of lithoautotrophic metabolism in Alcaligenes eutrophus, p. 244 -247. In R. L. Crawford and R. S. Hanson (ed.), Microbial Growth on C1 compounds. American Society for Microbiology, Washington, DC.
  • Friedrich, C. G., and B. Friedrich. 1983. Regulation of hydrogenase formation is temperature sensitive and plasmid coded in Alcaligenes eutrophus. J Bacteriol. 153:176-81.  PubMed
  • Friedrich, B., M. Meyer, and H. G. Schlegel. 1983. Transfer and expression of the herbicide-degrading plasmid pJP4 in aerobic autotrophic bacteria. Arch Microbiol. 134:92-7.  PubMed
  • Friedrich, C. G., K. Schneider, and B. Friedrich. 1982. Nickel in the catalytically active hydrogenase ofAlcaligenes eutrophus. J Bacteriol. 152:42-8.  PubMed
  • Srivastava, S., M. Urban, and B. Friedrich. 1982. Mutagenesis of Alcaligenes eutrophus by insertion of the drug-resistance transposon Tn5. Arch Mikrobiol. 131:203-7.  PubMed
  • Schlesier, M., and B. Friedrich. 1982. Effect of molecular hydrogen on histidine utilization by Alcaligenes eutrophus. Arch Microbiol. 132:260-265. 
  • Gerstenberg, C., B. Friedrich, and H. G. Schlegel. 1982. Physical evidence for plasmids in autotrophic, especially hydrogen-oxidizing bacteria. Arch Microbiol. 133:90-96.  PubMed  
  • Schlesier, M., and B. Friedrich. 1982. Histidine utilization by Alcaligenes eutrophus: regulation of histidase formation under heterotrophic conditions of growth. Arch Microbiol. 132:254-259. 
  • Friedrich, B., E. Heine, A. Finck, and C. G. Friedrich. 1981. Nickel requirement for active hydrogenase formation in Alcaligenes eutrophus. J Bacteriol. 145:1144-9.  PubMed
  • Friedrich, B., C. Hogrefe, and H. G. Schlegel. 1981. Naturally occurring genetic transfer of hydrogen-oxidizing ability between strains of Alcaligenes eutrophus. J Bacteriol. 147:198-205.  PubMed
  • Schlesier, M., and B. Friedrich. 1981. In vivo inactivation of soluble hydrogenase of Alcaligenes eutrophus. Arch Microbiol. 129:150-3.  PubMed
  • Friedrich, C. G., B. Friedrich, and B. Bowien. 1981. Formation of enzymes of autotrophic metabolism during heterotrophic growth of Alcaligenes eutrophus. J Gen Microbiol. 122:69-78. 
  • Schlegel, H. G., M. E. K. Ibrahim, E. Wilde, K. Schneider, M. Schlesier, B. Friedrich, and K. A. Malik.1981. Detrimental and beneficial effects of oxygen exerted on hydrogen-oxidizing bacteria, p. 107-129. In J. M. Lyons, R. C. Valentine, D. A. Phillips, D. W. Rains, and R. C. Huffaker (ed.), Genetic engineering of symbiotic nitrogen fixation, vol. 17. Plenum Press, New York.
  • Friedrich, B., and B. Magasanik. 1979. Enzymes of agmatine degradation and the control of their synthesis in Klebsiella aerogenes. J Bacteriol. 137:1127-33.  PubMed
  • Friedrich, C. G., B. Bowien, and B. Friedrich. 1979. Formate and oxalate metabolism in Alcaligenes eutrophus. J Gen Microbiol. 115:185-192. 
  • Friedrich, B., C. G. Friedrich, and B. Magasanik. 1978. Catabolic N2-acetylornithine 5-aminotransferase ofKlebsiella aerogenes: control of synthesis by induction, catabolite repression, and activation by glutamine synthetase. J Bacteriol. 133:686-91.  PubMed
  • Friedrich, B., and B. Magasanik. 1978. Utilization of arginine by Klebsiella aerogenes. J Bacteriol. 133:680-5.  PubMed
  • Friedrich, B., and B. Magasanik. 1977. Urease of Klebsiella aerogenes: control of its synthesis by glutamine synthetase. J Bacteriol. 131:446-52.  PubMed
  • Friedrich, B., C. G. Friedrich, and H. G. Schlegel. 1976. Purification and properties of chorismate mutase-prephenate dehydratase and prephenate dehydrogenase from Alcaligenes eutrophus. J Bacteriol. 126:712-22.  PubMed
  • Friedrich, C. G., B. Friedrich, and H. G. Schlegel. 1976. Regulation of chorismate mutase-prephenate dehydratase and prephenate dehydrogenase from Alcaligenes eutrophus. J Bacteriol. 126:723-32.  PubMed
  • Friedrich, C. G., B. Friedrich, and H. G. Schlegel. 1976. Aromatic amino acid biosynthesis in Alcaligenes eutrophus H 16 III. Properites and regulation of anthranilate synthase. Arch Microbiol. 107:125-31.  PubMed
  • Friedrich, B., and H. G. Schlegel. 1975. Aromatic amino acid biosynthesis in Alcaligenes eutrophus H16. II. The isolation and characterization of mutants auxotrophic for phenylalanine and tyrosine. Arch Microbiol.103:141-9.  PubMed
  • Friedrich, B., and H. G. Schlegel. 1972. [Hydroxylation of phenylalanine by Hydrogenomonas eutrophaH16]. Arch Mikrobiol. 83:17-31.  PubMed

Mitwirkung an folgen Stellungnahmen (Auswahl) im Rahmen der Politikberatung und Öffentlichkeitskommunikation

  • Nationale Akademie der Wissenschaften Leopoldina (Hrsg.), Deutsche Forschungsgemeinschaft, acatech ‒ Deutsche Akademie der Technikwissenschaften, Union der deutschen Akademien der Wissenschaften. 2015. Chancen und Grenzen des genome editing / The Opportunities and Limits of genome editing. Halle (Saale).
  • Nationale Akademie der Wissenschaften Leopoldina. 2015. Leopoldina-Diskussion Nr. 4 - Freiheit und Verantwortung der Wissenschaft: Rechtfertigen die Erfolgschancen von Forschung ihre potentiellen Risiken? Dokumentation des Symposiums der Nationalen Akademie der Wissenschaften Leopoldina, der Deutschen Forschungsgemeinschaft und des Deutschen Ethikrates am 3. November 2014 in Halle (Saale). Halle (Saale)
  • Nationale Akademie der Wissenschaften Leopoldina, acatech ‒ Deutsche Akademie der Technikwissenschaften, Union der deutschen Akademien der Wissenschaften. 2015. Akademien nehmen Stellung zu Fortschritten der molekularen Züchtung und zum erwogenen nationalen Anbauverbot gentechnisch veränderter Pflanzen. Ad-hoc-Stellungnahme abrufbar unter: Leopoldina.
  • Nationale Akademie der Wissenschaften Leopoldina (Hrsg.), acatech ‒ Deutsche Akademie der Technikwissenschaften, Union der deutschen Akademien der Wissenschaften. 2014. Individualisierte Medizin – Voraussetzungen und Konsequenzen. Halle (Saale).
  • Deutsche Forschungsgemeinschaft (Hrsg.) und Nationale Akademie der Wissenschaften Leopoldina. 2014. Wissenschaftsfreiheit und Wissenschaftsverantwortung – Empfehlungen zum Umgang mit sicherheitsrelevanter Forschung/ Scientific Freedom and Scientific Responsibility – Recommendations for the Handling of Security-Relevant Research. Bonn.
  • Nationale Akademie der Wissenschaften Leopoldina (Hrsg.). 2014. Zukunftsreport Wissenschaft. Lebenswissenschaften im Umbruch – Herausforderungen der Omics-Technologien für Deutschlands Infrastrukturen in Forschung und Lehre. Halle (Saale).
  • Nationale Akademie der Wissenschaften Leopoldina (Hrsg.). 2012. Bioenergie: Möglichkeiten und Grenzen. Halle (Saale).
  • Deutsche Forschungsgemeinschaft (Hrsg.), Nationale Akademie der Wissenschaften Leopoldina, acatech – Deutsche Akademie der Technikwissenschaften. 2009. Synthetische Biologie. Berlin Heidelberg.


Kontakt über das Sekretariat der Wissenschaftlichen Direktorin: 
Kathleen Carls

Telefon +49 (0) 3834 420 5001
Telefax +49 (0) 3834 420 5005
kathleen.carls(at)wiko-greifswald(dot)de