Infection Biology


The topic “Co-infection of Bacteria and Viruses” includes state-of-the-art presentations on bacterial and viral interactions with the human or animal host as well as recent advances in the understanding of co-infection mechanisms and pathophysiology. The summer school program addresses established experts and young scientists working in microbio- logy, virology and infection biology. It combines keynote lectures, oral presentations, workshops and posters, and a panel discussion on One Health issues.

Scientific Organizers:
Professor Dr. Sven Hammerschmidt University of Greifswald
Professor Dr. Dr. h.c. Thomas C. Mettenleiter Friedrich-Loeffler-Institut Federal Research Institute for Animal Health
Professor Dr. Barbara M. Bröker Greifswald University Medicine


Confirmed Speakers

  • Marylyn M. Addo (Universitätsklinikum Hamburg-Eppendorf, Germany)
  • Dunja Bruder (Otto-von-Guericke-University of Magdeburg, Germany)
  • Franz J. Conraths (Friedrich-Loeffler-Institut, Germany)
  • Fabian Deutskens (Ceva Santé Animale)
  • Christina Ehrhardt (Universitätsklinikum Jena, Germany)
  • Christian Gortázar (University of Castilla-La Mancha, Spain)
  • Barbara C. Kahl (Universitätsklinikum Münster, Germany)
  • Sascha Knauf (Friedrich-Loeffler-Institut, Germany)
  • Jesper Larsen (Statens Serum Institut, Denmark)
  • Jason Rosch (St Jude Children’s Research Hospital, Memphis, US)
  • Wilmara Salgado-Pabón (University of Wisconsin-Madison, US)
  • Bianca Schneider (Research Center Borstel, Germany)
  • Elma Tchilian (The Pirbright Institute, UK)
  • Dmitry Ushakov (Friedrich-Loeffler-Institut, Germany)
  • Peter Valentin-Weigand (Stiftung Tierärztliche Hochschule Hannover, Germany)
  • Jan-Willem Veening (University of Lausanne, Switzerland)
  • Andreas Wack (The Francis Crick Institute, UK)
  • Martin Witzenrath (Charité, Germany)

Monday, 26 September 2022
Venue: Alfried Krupp Wissenschaftskolleg Greifswald

13:00 Welcome

Christian Suhm, Alfried Krupp Kolleg Greifswald, Germany
Thomas C. Mettenleiter, Friedrich-Loeffler-Institut, Germany
Sven Hammerschmidt, University of Greifswald, Germany
Barbara Bröker, University Medicine Greifswald, Germany

Session I: New Insights in Bacto-Viral Co-Infections

Chairs:Nikolai Siemens, University of Greifswald, Germany
Lea A. Tölken, University of Greifswald, Germany
13:15 Host-related factors affecting susceptibility to tuberculosis: the role of coinfections and the biological sex
Bianca Schneider, Forschungszentrum Borstel - Leibniz Lungenzentrum, Germany

13:45 Maladapted epithelial response in the post-influenza lung as a potential driver for enhanced susceptibility to bacterial superinfection
Dunja Bruder, Universitätsmedizin Magdeburg, Germany

14:15 New Insights into Pneumococcal-Influenza Synergy
Jason Rosch, St. Jude Children’s Research Hospital, USA

14:45 New aspects of pathogen-host interactions during influenza virus and Staphylococcus aureus co-infection
Christina Ehrhardt, Universitätsklinikum Jena, Germany

15:15 Coffee break

Session II: Emerging infections: Analytical tools and visualization

Chairs:Thomas C. Mettenleiter, Friedrich-Loeffler-Institut, Germany
Emmelie Eckhardt, Friedrich-Loeffler-Institut, Germany
15:45 Visualizing SARS-CoV-2 infection in the respiratory tract of golden hamster
Dmitry Ushakov, Friedrich-Loeffler-Institut, Germany

16:15 Targeting translation - Natural compounds and their derivates against SARS-CoV-2
Cora M. Holicki, Friedrich-Loeffler-Institut, Germany

16:30 Analysis of the viral evolution of zoonotic RNA viruses in their natural host
Nele Marie Brinkmann, Bernhard Nocht Institute for Tropical Medicine, Germany

16:45 Impact of co-infections with West Nile virus and Usutu virus on the vector competence of Culex pipiens biotype molestus
Christin Körsten, Friedrich-Loeffler-Institut, Germany

17:00 Participatory risk mapping of African swine fever in Europe
Hannes Bergmann, Friedrich-Loeffler-Institut, Germany

17:15 Poster session in the foyer

Plenary Lecture
Chair: Barbara Bröker, University Medicine Greifswald, Germany
18:15 Tuberculosis and trained innate immunity: a One Health perspective
Christian Gortázar, University of Castilla-La Mancha · Sanidad y Biotecnología, Spain

Tuesday, 27 September 2022
Venues: Alfried Krupp Wissenschaftskolleg Greifswald
Friedrich-Loeffler-Institut Insel Riems

Session III: Aspects of One Health
Chairs:Fabian Leendertz, Helmholtz Institute for One Health, Greifswald
8:30 One Health - More Than Fighting Zoonoses
Sascha Knauf, Friedrich-Loeffler-Institut, Germany

9:00 One Health approach to monitor, understand and prevent zoonotic spillover infections in Nigeria
Anja Globig, Friedrich-Loeffler-Institut, Germany

9:15 The role of veterinarians & One Health Approach in Kuwait
Ahmad Alajmi, Public Authority of Agriculture Affairs & Fish Resources (PAAF), Kuwait

9:30 Using sentinel surveillance in a holistic approach to understand pathogen ecology
Francesca Isabel Rondi, Università degli Studi di Milano, Italy

9:45 One Health Simulation exercises: A practical example from the ECOWAS region.
Jakob Winter, Friedrich-Loeffler-Institut, Germany

10:00 Evolutionary history and zoonotic transmission of mecC-MRSA: the role of hedgehogs and antibiotic-producing dermatophytes
Jesper Larsen, Statens Serum Institut, Denmark

10:30 Coffee Break

Session IV: Host-Pathogen Interactions I
Chairs:Sven Hammerschmidt, University of Greifswald, Germany
Supradipta De, University of Greifswald, Germany
11:00 Pathophysiology of Pneumonia
Martin Witzenrath, Charité, Germany

11:30 Molecular view on the impact of gut metabolites on the intestinal pathogen Clostridioides difficile
Susanne Sievers, University of Greifswald, Germany

11:45 Characterizing the role of the small regulatory RNA FsrA in the iron limitation response of Staphylococcus aureus
Alexander Ganske, University Medicine Greifswald, Greifswald

12:00 Streptococcus pneumoniae affects human dendritic cell function in a pneumolysin dependent manner
Antje Paulikat, University of Greifswald, Germany

12:15 Systems and synthetic biology approaches to study pneumococcal pathogenesis
Jan-Willem Veening, University of Lausanne, Switzerland

12:45 Lunch break and poster session in the entrance foyer

14:00 Departure of the Bus to Insel Riems

14:45 The Friedrich-Loeffler-Institut – Past, Present and Future
Thomas C. Mettenleiter, Friedrich-Loeffler-Institut, Germany

15:30 Tour on Insel Riems

17:00 Panel Discussion: Preparedness, Prevention and Therapy

Moderation: Elke Reinking, Christian Suhm

Marylyn M. Addo, Universitätsklinikum Hamburg-Eppendorf, Germany
Barbara M. Bröker, Greifswald University Medicine, Germany
Franz J. Conraths, Friedrich-Loeffler-Institut, Germany
Fabian Deutskens, Ceva Santé Animale, Germany
Peter Valentin-Weigand, Stiftung Tierärztliche Hochschule Hannover, Germany

19:00 Barbecue
20:00 Early departure of the Bus to Greifswald
21:00 Late departure of the Bus to Greifswald

Wednesday, 28 September 2022
:   Alfried Krupp Wissenschaftskolleg Greifswald

Session V: Host-Pathogen Interactions II
Chairs:Stefan Finke, Friedrich-Loeffler-Institut, Germany
Ola Bagato, Friedrich-Loeffler-Institut, Germany
8:30 Various ways of adaptation of Staphylococcus aureus to the airways of people with cystic fibrosis during chronic infection
Barbara Kahl, Universitätsklinikum Münster, Germany

9:00 Plasminogen-mediated activation of avian influenza virus hemagglutinin H3 facilitates systemic infection including neurotropism
Jacob Schön, Friedrich-Loeffler-Institut, Germany

9:15 Neuraminidase stalk deletion decreased virulence and transmission of avian influenza viruses H5N8 and H7N7 in chickens and/or ducks
David Scheibner, Friedrich-Loeffler-Institut, Germany

9:30 Field Rabies Virus Glycoprotein Retention at Cytoplasmic Inclusion Bodies and Possible Implications on Intraneuronal Virus Transport and Release
Ola Bagato, Friedrich-Loeffler-Institut, Germany

9:45 Vector competence of German mosquitoes for Rift Valley fever virus
Amira AL-Hosary, Friedrich-Loeffler-Institut, Germany

10:00 Coffee Break

Session VI: Immune modulation
Chairs:Anca Dorhoi, Friedrich-Loeffler-Institut, Germany
Alexander Schäfer, Friedrich-Loeffler-Institut, Germany
10:30 Lung epithelia under attack: Infection, Interferons, Inflammation
Andreas Wack, The Francis Crick Institute, UK

11:00 Hyper-virulent Streptococcus pyogenes impairs interleukin-18 response in human immune cells of myeloid lineage
Lea A. Tölken, University of Greifswald, Germany

11:15 Investigating defense mechanisms against M. tuberculosis in macrophages from natural hosts
Fabian Stei, Friedrich-Loeffler-Institut, Germany

11:30 The Role of Paleoviral Sequences of Ebola Virus in Immune Tolerance
Christoph Henkel, Bernhard Nocht Institute for Tropical Medicine, Germany

11:45 The effect of PB1-F2 on the immune response against avian influenza H7N7 virus in Gallus gallus
Luise Hohensee, Friedrich-Loeffler-Institut, Germany

12:00 Staphylococcus aureus pathogenesis in infective endocarditis: the secret life of superantigens
Wilmara Salgado-Pabón, School of Veterinary Medicine UW–Madison, USA

12:30 Lunch break and poster session in the entrance foyer

Session VII: Animal models and new technologies
Chairs: Martin Beer, Friedrich-Loeffler-Institut, Germany
Sophie-Celine Weinert, Friedrich-Loeffler-Institut, Germany
13:15 The pig as a model to study immunity to respiratory diseases
Elma Tchilian, The Pirbright Institute, UK

13:45 Swine as a natural host and biomedical model for bacto-viral co-infections
Astrid Puppe, University of Greifswald, Germany

14:00 Protein expression of Streptococcus  pneumoniae in experimental mouse infection models
Sven Hammerschmidt, University of Greifswald, Germany

14:15 Inherent differences in lymphocyte populations of domestic pigs and wild boar indicate a potential explanation for disparate outcome of viral disease
Alexander Schäfer, Friedrich-Loeffler-Institut, Germany

14:30 Application of Computer Vision in Animal Experiments with Red Foxes
Anne Schütz, Friedrich-Loeffler-Institut, Germany

14:45 Farewell

Sven Hammerschmidt, University of Greifswald, Germany
Thomas C. Mettenleiter, Friedrich-Loeffler-Institut, Germany
Barbara Bröker, University Medicine Greifswald, Germany
Christian Suhm, Alfried Krupp Kolleg Greifswald, Germany

Contact: maja.richertmed.uni-greifswaldde

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