Macrophage (re-)programming in viral pneumonia: role in lung injury and stem-cell-mediated repair

Öffentlicher Abendvortrag
Foto: privat

CX3CR1pos monocytes are mobilized upon infection and undergo monocyte-to-macrophage transition in inflamed tissues. We demonstrate that during severe viral pneumonia, bone marrow-derived macrophages pass co-ordinated trajectories of pro-inflammatory, tissue-damaging to tissue-healing phenotypes, before differentiating into tissue-resident alveolar macrophages, that retain a long-term tissue-protective phenotype. This phenotype is characterized by expression of defined markers and effector molecules. Combining high dimensional single cell transcriptomics with complex lung organoid modeling, in vivo adoptive cell transfer and macrophage-specific gene targeting, we reveal important mediators of macrophage-epithelial cross-talk during lung injury and barrier repair. Targeting or using such effector molecules significantly impact viral lung injury, and rescue mice from otherwise fatal disease, highlighting the therapeutic potential of macrophage targeting.

Susanne Herold´s research addresses the molecular mechanisms of phagocyte-epithelial cell interactions during pathogen-induced lung injury regarding host defense, epithelial barrier function, and stem cell niche-mediated tissue regeneration, with a focus on influenza virus pneumonia. Her projects aim at defining novel therapeutic targets for treatment to attenuate lung injury and to foster organ regeneration in severe lung infection in a translational bench-to-bedside approach. 
She received an MD title (Dr. med.) in 2003 and followed a clinician-scientist career path as member of the International Graduate Program “Molecular Biology and Medicine of the Lung” where she graduated with a PhD title in 2008 at the Justus-Liebig University. She got board-certified in Internal Medicine, Infectious Diseases and Pulmonary Medicine. Since 2013 she is an Adjunct Professor at Northwestern University, Feinberg School of Medicine (Division of Pulmonary and Critical Care Medicine), became DZL W2 Professor for Acute Lung Injury at the JLU Giessen in 2015, and W3 Professor for Pulmonary Infections in 2018, the latter associated with the Coordinator Position of the DFG-funded Clinical Research Unit 309 “Virus-induced Lung Injury” (KFO309) and the Clinical Section Chair for Infectious Diseases at the Department of Medicine II. Since 2022 she is director of the Department of Medicine V, Internal Medicine, Infectious Diseases and Infection Control, University Hospital Gießen und Marburg (UKGM) and Chair for Internal Medicine and Pulmonary Research.
She is Deputy Editor of the American Journal of Respiratory Cell and Molecular Biology of the American Thoracic Society, Co-Speaker of the Berlin-Gießen SFB TR84 “Innate Immunity of the Lung” and Steering Member of the DFG-funded Clinician-Scientist Program “JLU-CAREER”.

Moderation: Professorin Dr. Barbara M. Bröker


Unfortunately, Prof. Herold cannot come and will give the lecture digitally. However, it is possible to watch the live stream in the lecture hall of the Kolleg.


Access to the lecture hall

Organizational information on the digital lecture
The Alfried Krupp Wissenschaftskolleg is offering this event live as a zoom meeting, in which viewers can also take part in the subsequent discussion with video contributions, too.

  • We would be delighted if you gave your real name when dialing into Zoom. Of course, you can also take part in the event under a pseudonym.
  • A list of all participants is available to all those involved during the entire event.
  • During the lecture, the microphones of the audience are all automatically muted so as not to generate any disturbing background noise. You can turn on the audience's camera during the lecture.
  • In the discussion that follows, requests to speak or questions can be displayed using the "Raise hand" function. You can find these - depending on the device - under the button "Participant", "More" or "Reactions" in Zoom. You can also lower your hand again if you want to withdraw the question.
  • The moderator keeps a speech list and gives the floor in the order of the messages. If the moderator asks you to bring your question or request to speak, the user interface will ask you to turn on your microphone. If you have not already done so, you are welcome to turn on your camera. This is particularly desirable when presenting longer requests to speak so that the presenter can also see who is asking the question or who is making the comment.
  • Of course, you also have the option of asking your questions in writing in the chat.

Recording of the digital lecture
The digital lecture will be recorded so that it can be used in the college's media library. Only the speaker, his / her presentation and the moderator can be heard or seen in the recording. Video, audio or chat contributions are not recorded. A “REC” symbol at the edge of the screen informs the participants about the current recording.

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